RESEARCH ARTICLES
The following research articles have been collated from
various research organizations and publishers.
CellPlus (Polymeric Organic Acids - Fulvic and Humic Acids)
‘Humic substances not only improve the immune system, but also have anti-inflammatory, antioxidant and antiviral activities against human RNA viruses. Therefore, while the entire world is preparing to deal with alarming threat of community spread of COVID-19, Humic substances may play a vital role in improving the innate immunity for prevention and management of SARS-CoV-2 infection’
Koul, D; Khosla, J. K; & Manhas, R. S; Chander, D; and Chaubey, A. COVID-19 prevention and management: Potential applications of humic substances. Integrative Medicine Case Reports. (2021) 2. 61.
‘Humic acid (HA) induces apoptosis and has various pharmacological properties including anti-inflammatory and anti-proliferative effects. In our study, we examined the cytotoxic effects of HA at concentrations of 5, 10, 20, 50 and 100 μg/mL in human breast adenocarcinoma MCF-7 cell line for 24 and 48 h.’
Aykac, A.; Becer, E.; Okcanoğlu, T.B.; Güvenir, M.; Süer, K.; Vatansever, S. The Cytotoxic Effects of Humic Acid on Human Breast Cancer Cells. Proceedings of The 2nd International Cell Death Research Congress 2018, 2, 1565.
‘Fulvic acid (FvA), comes from humic substances produced by microorganisms in soil. Traditional medicine and modern research claim FvA can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function; all of which are hallmarks of diabetes.’
Winkler J, Ghosh S. Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes. J Diabetes Res. 2018 Sep 10;2018:5391014.
‘Even picomolar concentration ranges of humic substances, Vitamin C and Zn/Se ions in the given composition, were enough to achieve 50% viral replication inhibition in the applied SARS-CoV-2 virus inhibition test.’
Hajdrik, P., Pályi, B., Kis, Z., Kovács, N., Veres, D.S., Szigeti, K., Budán, F., Hegedüs, I., Kovács, T., Bergmann, R., & Máthé, D. (2022).In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication. Foods, 11.
‘Evidence that micronutrient malnutrition increases late onset diseases, such as cancer, is discussed. A multivitamin -mineral supplement is one low-cost way to ensure intake of the Recommended Dietary Allowance of micronutrients throughout life.’
Ames, B. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage.Proceedings of the National Academy of Sciences of the United States of America 103, no. 47 (2006): 17589–94.
‘Fulvic-acid inhibited the proliferation of all the cell lines used in this study determined by MTT analysis. Specifically, Hep3B cells were found to be most sensitive for 48-hour application with 1.58–2.43 μg/μL IC50 value.’
Aydin SK, Dalgic S, Karaman M, Kirlangic OF, Yildirim H. Effects of Fulvic Acid on Different Cancer Cell Lines. Proceedings. 2017; 1(10):1031.
‘Efficiency of therapeutic compounds could be enhanced by encapsulation and covalent attachments to a biomaterial carrier. Complex formation with humic substances is valuable techniques to improve bioactivity of natural products. Fractal structures of humic substances also have adjacent carboxyl and hydroxyl groups. Along with molecular bonding property, reduction-oxidation and association-dissociation capacities of humic substances are considered this as a biomaterial for transform, other molecules, and substances. Immune system responses of humic acid stimulates in the human body.’
Jacob, K. K., Prashob, K. J. P., and Chandramohanakumar, N., (2019). Humic Substances as a potent biomaterials for therapeutic and drug delivery system – A review. International Journal of Applied Pharmaceutics, 11(3), 1–4.
‘Fulvic acid is a promising topical remedy for drug-resistant wound infections. It accelerated the healing process of wounds infected with methicillin-resistant S. aureus and multidrug-resistant P. aeruginosa in rats, which is linked to both its antimicrobial and anti-inflammatory properties.’
Zhao, Yanan PhD; Paderu, Padmaja MSc; Delmas, Guillaume MSc; Dolgov, Enriko MD; Lee, Min Hee; Senter, Meredith; Park, Steven; Leivers, Stephen MSc; Perlin, David S. PhD.
Carbohydrate-derived fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens. Journal of Trauma and Acute Care Surgery: October 2015 – Volume 79 – Issue 4 – p S121-S129
‘Humic acid based complex microelement supplementation is recommended as an effective tool for prevention and health protection in occupational cadmium exposure as well as for smokers known to be considerably burdened by cadmium.’
Hudák A, Náray M, Nagy I, Molnár M, Gömöry I, Ungváry G. The favorable effect of humic acid based complex micro-element preparations in cadmium exposure.Orv Hetil. 1997 Jun 1; 138 (22): 1411-6. Hungarian.
‘Our findings indicated that humic acids inhibited the antimicrobial effect of glyphosate on different bacteria. This information can help overcome the negative impact of glyphosate residues in feed and water.’
Shehata AA, Kühnert M, Haufe S, Krüger M. Neutralization of the antimicrobial effect of glyphosate by humic acid in vitro. Chemosphere. 2014 Jun; 104:258-61.
‘Shilajit and HA possess anti-inflammatory, antioxidant, antimutagenic, antitoxic, antiviral, heavy metal chelating, antitumor, apoptotic and photo-protective properties. These properties make Shilajit useful agents for cancer therapy and prevention. In addition, Shilajit has no reported side effects and can be administered as a nutritive and rejuvenating tonic and combats age related problems.’
Pant, K; Singh, B. and Thakur, N. (2012). Shilajit: A humic matter panacea for cancer. International Journal of Toxicological and Pharmacological Research. 4. 17-25.
‘Fulvic acid (FA), a humic substance, has several nutraceutical properties, including anti-inflammation, antimicrobial, and immune regulation abilities. The no-observed-adverse-effect-level (NOAEL) of FA supplementation from the 60-day study was determined to be 5,000 mg/kg body weight/day, the highest dose tested. Our findings suggest that the oral administration of FA may have higher safety.’
Dai C, Xiao X, Yuan Y, Sharma G, Tang S. A Comprehensive Toxicological Assessment of Fulvic Acid.Evid Based Complement Alternat Med. 2020 Dec 16;2020